Cold Plate Spray HEPA Box In Pharmaceutical Research And Development

1. Definition and Purpose:

   • The Cold Plate Spray HEPA Box is a specialized type of HEPA enclosure that incorporates a chilled surface or "cold plate" within the work area.
   • This design feature is primarily used to provide a temperature-controlled environment for processes that require precise temperature management, such as certain chemical reactions or delicate sample handling.

2. Cold Plate Functionality:

   • The cold plate within the HEPA Box is typically made of a highly conductive material, such as aluminum or copper, and is connected to a cooling system.
   • This cooling system, which may utilize refrigeration or thermoelectric technology, allows the temperature of the cold plate to be precisely controlled and maintained at the desired set point.
   • The cold plate serves to create a localized cold work zone within the overall HEPA-filtered environment, enabling temperature-sensitive operations to be carried out in a clean and controlled manner.

3. Design and Construction:

   • The Cold Plate Spray HEPA Box features a transparent enclosure, similar to a standard HEPA Box, but with the addition of the cold plate situated within the work area.
   • The box may also include features such as:
     • Adjustable airflow controls to maintain the desired laminar air pattern
     • Temperature monitoring and feedback systems to ensure precise temperature regulation
     • Integrated lighting for improved visibility
     • Additional ergonomic or user-friendly design elements

4. Applications and Use Cases:

   • The Cold Plate Spray HEPA Box is primarily utilized in applications where precise temperature control is crucial, such as:
     • Pharmaceutical research and development
     • Biotechnology and life science experiments
     • Microelectronics and semiconductor manufacturing
     • Analytical chemistry and materials science
     • Cryogenic sample handling and storage

5. Operational Considerations:

   • Users of the Cold Plate Spray HEPA Box must follow strict protocols to maintain the integrity of the clean and temperature-controlled environment, including proper gowning, minimizing disruptions to the airflow, and performing regular cleaning and maintenance.
   • Calibration and validation of the temperature control system are essential to ensure the desired temperature set points are accurately maintained throughout the work process.

The Cold Plate Spray HEPA Box combines the benefits of a high-efficiency HEPA filtration system with the capability to provide a precisely controlled, temperature-regulated work environment. This specialized design makes it a valuable tool for industries and research fields that require both cleanliness and temperature management for their critical processes.

Definition: HEPA box is the terminal device in purified air supply system.

Operation Principle: The HEPA box requiring filed leak detection is provided with PAO dusty entry and upstream concentration detection mouth, and differential pressure detection mouth and lower damper based on customers’ requirements.

Advantages of ABS HEPA Box

• One time injection, no leakage risk, smooth inner surface, dust-free and easy to clean.

• Acid, alkali and salt-resistant, formaldehyde-resistant, VHP and O 3 Sterilize.

Advantages of Plastic-spray Steel Plate

• Full welding with mechanical welding machine, high efficiency.

• No leakage risk.

• The box is not easy to deform.

Standard size and Parameter

Note: For ABS box,the hole size should be 5mm larger than that in the list,for plastic-spray box with DOP outside,the hole size should be 5mm smaller than that in the list .We can also produce other sizes according to customer’s requirements. 

Production Process

Company Profile

LENGE purification equipment are the manufacturer of over 25 years of experience, expertise and research in air and

liquid filtration. We offer innovative purification solutions that set standards and help factories to improve the quality of

production.